U.S. Food and Drug Administration
Ozone has been given GRAS (Generally Recognized as Safe) approval by the FDA for direct contact with food products, including all meat and poultry products. While good manufacturing procedures must be in place, no regulations exist on levels of ozone in food processing applications. The final rule from the FDA providing GRAS approval was given in 2001, the USDA followed with the final rule granting GRAS approval for ozone in 2002. Reference for all this actions.
U.S. Department of Agriculture
USDA final rule on ozone dated 12/17/2002, FSIS Directive 7120.1 states: safe and suitable ingredients used in the production of meat and poultry. Ozone can be used in accordance with current industry standards of good manufacturing practice. No other guidelines are given on levels or dosages of ozone.
Reference 21 CFR 173.368 - Ozone (CAS Reg. No. 10028-15-6) may be safely used in the treatment, storage, and processing of foods, including meat and poultry (unless such use is precluded by standards of identity in 9 CFR part 319), in accordance with the prescribed conditions.
U.S. Environmental Protection Agency
ExOzone® technology and appliances are disposing with the registration of the pesticide-producing and device-producing establishment.
EPA establishment number: 93758-HUN-1